PROF ELIZABETH HELEN BLACKBURN AC (1948 – ) is one of only 48 women to have won a Nobel Prize. That’s out of the 900 Laureates who have received this distinction since 1901. Elizabeth was awarded a Nobel Prize for Physiology or Medicine in 2009, along with Americans Dr Jack W Szostak and Professor Carol W Greider, for figuring out how our DNA ages. In the 1970s Elizabeth and her colleagues made a discovery that explained how DNA eventually begins to deteriorate and how this, in turn, ages us. They found that young DNA is protected by little ‘caps’, called telomeres, at the end of our chromosomes. These caps, with the help of an enzyme called telomerase, stop our chromosomes from deteriorating. Every time a cell divides, the telomeres are worn down a little and it’s the enzyme’s job is to try to rebuild them. But eventually the telomeres are worn down, and once they are beyond repair, cell death is triggered. This eventual wear and tear on our chromosomes is one of the reasons our bodies age. If we can stop telomeres from deteriorating we may be able to slow the ageing process and extend life by an extra five to 30 years. Telomeres are also thought to play a key role in cancers, such as pancreatic, bone, prostate, bladder, lung, kidney, and head and neck cancer. In the future, if telomerase can be controlled, these cancers may be preventable.
Pictured (L – R) Gregory Boyle, Mrs Ed Roberts, Amy Tan, Jerry Brown, Ann Brown, Magic Johnson, Al Jardine, Buzz Aldrin, Elizabeth Blackburn, and Carlos Santana attend the 2011 California Hall of Fame Inductee Ceremony at the California Museum. Elizabeth currently lives in the USA.